After two decades working in the industry and five Oscar nominations, will this finally be the year that Leo walks away with the Academy Award for Best Actor?
In the run up to Sunday night's award ceremony we have taken a look back at the films that have made Leonardo the Hollywood heavyweight that he is today.
Which is your favorite Leo movie? Let us know on Twitter @hellomagus
2/14
What's Eating Gilbert Grape - 1993
Leo impressed as a mentally disabled teenager in a small Midwestern town – earning the first of five Oscar nominations for acting and stealing the thunder of Johnny Depp, then the more established name.
Photo: Paramount pictures
3/14
The Basketball Diaries - 1995
An adaptation of counter-culture author Jim Carroll's memoir about drug addiction, this was the first of many films in which the actor played a real-life character
Photo: Metro-Goldwyn-Mayer Studios
4/14
Romeo and Juliet - 1996
Baz Luhrmann's high-octane update of the Shakespeare play paired him with Claire Danes.
Photo: 20th Century Fox
5/14
Titanic - 1997
This time Kate Winslet was his love interest in the movie that sparked Leomania worldwide.
Photo: Paramount Pictures
6/14
The Gangs of New York - 2002
The actor fulfilled a lifelong dream by working with Martin Scorsese in this tale of 19th-century street warfare.
Photo: Miramax Films
7/14
Catch Me If You Can - 2002
The crime drama brought the story of America’s youngest con artist, Frank Abagnale Jr, to the big screen.
Photo: Dreamworks LLC
8/14
The Aviator - 2004
In his second Scorsese film Leo played real-life millionaire Howard Hughes.
Photo: Warner Bros.
9/14
Blood Diamond - 2006
Motivated by his interest in social and environmental issues, Leo lent his talent to a film about the illegal trade in conflict diamonds.
Photo: Warner Bros.
10/14
Shutter Island - 2010 A psychological thriller about the line between madness and sanity.
Photo: Paramount Pictures
11/14
Inception - 2010
Christopher Nolan's science fiction heist thriller about a thief of memories.
Photo: Warner Bros.
12/14
Django Unchained - 2012
Leo had great fun playing the moustache-twirling baddie in Quentin Tarantino's bloody slave drama.
Photo: The Weinstein Company
13/14
The Great Gatsby - 2013
Once again directed by Baz Luhrmann, he took on the classic tragic American hero.
Photo: Warner Bros.
14/14
The Wolf of Wall Street - 2014
His fourth Oscar nomination came for starring in rogue stockbroker Jordan Belfort's tale of the high life in the financial district. The film was another collaboration with Scorsese.